Learning combinatorial transcriptional dynamics from gene expression data

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Large-scale learning of combinatorial transcriptional dynamics from gene expression

MOTIVATION Knowledge of the activation patterns of transcription factors (TFs) is fundamental to elucidate the dynamics of gene regulation in response to environmental conditions. Direct experimental measurement of TFs' activities is, however, challenging, resulting in a need to develop statistical tools to infer TF activities from mRNA expression levels of target genes. Current models, however...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2010

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btq244